Cell competition in mammals — novel homeostatic machinery for embryonic development and cancer prevention

Takeshi Maruyama, Yasuyuki Fujita

研究成果: Review article査読

50 被引用数 (Scopus)

抄録

In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition and was originally discovered in Drosophila. Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium; a process termed EDAC (Epithelial Defense Against Cancer). Furthermore, physical force can play a crucial role in the intercellular recognition and elimination of loser cells during cell competition. Further studies are expected to reveal a variety of roles of cell competition in embryonic development and human diseases.

本文言語English
ページ(範囲)106-112
ページ数7
ジャーナルCurrent Opinion in Cell Biology
48
DOI
出版ステータスPublished - 2017 10
外部発表はい

ASJC Scopus subject areas

  • 細胞生物学

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