Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate

Yajing Shen, Yu Cheng*, Taro Q.P. Uyeda, Gustavo R. Plaza

*この研究の対応する著者

研究成果: Review article査読

6 被引用数 (Scopus)

抄録

The use of magnetic nanoparticles (MNPs) is a promising technique for future advances in biomedical applications. This idea is supported by the availability of MNPs that can target specific cell components, the variety of shapes of MNPs and the possibility of finely controlling the applied magnetic forces. To examine this opportunity, here we review the current developments in the use of MNPs to mechanically stimulate cells and, specifically, the cell mechanotransduction systems. We analyze the cell components that may act as mechanosensors and their effect on cell fate and we focus on the promising possibilities of controlling stem-cell differentiation, inducing cancer-cell death and treating nervous-system diseases.

本文言語English
ページ(範囲)2475-2486
ページ数12
ジャーナルAnnals of Biomedical Engineering
45
10
DOI
出版ステータスPublished - 2017 10 1

ASJC Scopus subject areas

  • 生体医工学

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