Background and objective: Reduction in cerebral blood ﬂow with aging leads to cognitive decline and brain atrophy. Cerebrovascular hemodynamics are associated with vascular function. However, little is known about endothelial function in relation to cerebral blood ﬂow at rest. The present study aimed to examine the association between microvascular endothelial function and middle cerebral blood ﬂow. Material and methods: This study involved 60 healthy middle-aged and elderly men. The microvascular endothelial function was measured via digital reactive hyperemia index using pulse amplitude tonometry, and the mean middle cerebral blood ﬂow velocity and cerebrovascular conductance were measured using transcranial Doppler ultrasonography. Results and conclusions: Reactive hyperemia index was signiﬁcantly correlated with the mean middle cerebral blood ﬂow velocity and cerebrovascular conductance. Multiple regression analysis further indicated that the correlation was signiﬁcant after adjustment of covariates, such as age, body mass index, smoking status, medication history, blood pressure, and arterial stiffness. Further, Reactive hyperemia index was found to be a signiﬁcant independent determinant of the mean middle cerebral blood ﬂow velocity and cerebrovascular conductance. The present study demonstrated that vascular endothelial function is associated with cerebral blood ﬂow and is an independent potential confounding factor in healthy middle-aged and older men.
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