Cerebral glucose metabolism associated with a fear network in panic disorder

Yojiro Sakai, Hiroaki Kumano, Masami Nishikawa, Yuji Sakano, Hisanobu Kaiya, Etsuko Imabayashi, Takashi Ohnishi, Hiroshi Matsuda, Asako Yasuda, Atsushi Sato, Mirko Diksic, Tomifusa Kuboki

研究成果: Article

136 引用 (Scopus)

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The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.

元の言語English
ページ(範囲)927-931
ページ数5
ジャーナルNeuroReport
16
発行部数9
DOI
出版物ステータスPublished - 2005 6 21
外部発表Yes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Sakai, Y., Kumano, H., Nishikawa, M., Sakano, Y., Kaiya, H., Imabayashi, E., Ohnishi, T., Matsuda, H., Yasuda, A., Sato, A., Diksic, M., & Kuboki, T. (2005). Cerebral glucose metabolism associated with a fear network in panic disorder. NeuroReport, 16(9), 927-931. https://doi.org/10.1097/00001756-200506210-00010