CFD and PIV analysis of hemodynamics in a growing intracranialaneurysm

Marcelo Raschi*, Fernando Mut, Greg Byrne, Christopher M. Putman, Satoshi Tateshima, Fernando Viñuela, Tetsuya Tanoue, Kazuo Tanishita, Juan R. Cebral

*この研究の対応する著者

研究成果: Article査読

54 被引用数 (Scopus)

抄録

Hemodynamics is thought to be a fundamental factor in the formation, progression, and rupture of cerebral aneurysms. Understanding these mechanisms is important to improve their rupture risk assessment and treatment. In this study, we analyze the blood flow field in a growing cerebral aneurysm using experimental particle image velocimetry (PIV) and computational fluid dynamics (CFD) techniques. Patient-specific models were constructed from longitudinal 3D computed tomography angiography images acquired at 1-y intervals. Physical silicone models were constructed from the computed tomography angiography images using rapid prototyping techniques, and pulsatile flow fields were measured with PIV. Corresponding CFD models were created and run under matching flow conditions. Both flow fields were aligned, interpolated, and compared qualitatively by inspection and quantitatively by defining similarity measures between the PIV and CFD vector fields. Results showed that both flow fields were in good agreement. Specifically, both techniques provided consistent representations of the main intra-aneurysmal flow structures and their change during the geometric evolution of the aneurysm. Despite differences observed mainly in the near wall region, and the inherent limitations of each technique, the information derived is consistent and can be used to study the role of hemodynamics in the natural history of intracranial aneurysms.

本文言語English
ページ(範囲)214-228
ページ数15
ジャーナルInternational Journal for Numerical Methods in Biomedical Engineering
28
2
DOI
出版ステータスPublished - 2012 2
外部発表はい

ASJC Scopus subject areas

  • 計算理論と計算数学
  • ソフトウェア
  • 応用数学
  • モデリングとシミュレーション
  • 生体医工学
  • 分子生物学

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