Characterization of amyloid β protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay

Naoya Sawamura, Akira Tamaoka, Shi N.Ichi Shoji, Edward H. Koo, Lary C. Walker, Hiroshi Mori

研究成果: Article

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We analyzed the composition of amyloid β protein (A β) species in cerebral amyloid angiopathy (CAA) of an aged squirrel monkey. Immunocytochemistry demonstrated that the cerebral cortex contained no lesions other than widespread CAA with A β40 as its apparent major component. However, enzyme-linked immunosorbent assay revealed that A β42(43) predominated over A β40 in a formic acid-extracted cortical fraction. These findings suggest possible underestimation of A β42(43) levels in some previous immunocytochemical investigations.

元の言語English
ページ(範囲)225-229
ページ数5
ジャーナルBrain Research
764
発行部数1-2
DOI
出版物ステータスPublished - 1997 8 1

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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