Characterization of cDNA encoding full-length mouse platelet glycoprotein IX

T. Kitaguchi, M. Murata*, H. Ambo, Y. Ikeda

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Glycoprotein (GP) IX is a platelet membrane 20 kD protein, which is associated with GPIba, GPIbβ, and GPV to form GPIb/IX/V complex. GPIb/IX/V complex is a major receptor for yon Willebrand factor, which mediates platelet adhesion and aggregation under high shear stress conditions. The relevance of this receptor for hemostasis has been implicated by a congenital bleeding disorder lacking the receptor, Bernard-Soulier syndrome. All subunits for the human receptor have been cloned and characterized. However, the function of GPIX is still elusive. To obtain further information of GPIX, we have determined a cDNA sequence of mouse GPIX (811 bp). The deduced amino- acid sequence (177aa) was 71% identical to the human GPIX protein. All cysteine residues in extracytoplasmic domain and putative N-linked glycosylation site (Asn44) were conserved. Mouse GPIX contained a leucine- rich glycoprotein sequence composed of 24 amino acids, as did human GPIX.

本文言語English
ページ(範囲)381-385
ページ数5
ジャーナルBlood Coagulation and Fibrinolysis
9
4
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 血液学

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