Characterization of cDNA encoding full-length mouse platelet glycoprotein IX

T. Kitaguchi, M. Murata, H. Ambo, Y. Ikeda

研究成果: Article

3 引用 (Scopus)

抜粋

Glycoprotein (GP) IX is a platelet membrane 20 kD protein, which is associated with GPIba, GPIbβ, and GPV to form GPIb/IX/V complex. GPIb/IX/V complex is a major receptor for yon Willebrand factor, which mediates platelet adhesion and aggregation under high shear stress conditions. The relevance of this receptor for hemostasis has been implicated by a congenital bleeding disorder lacking the receptor, Bernard-Soulier syndrome. All subunits for the human receptor have been cloned and characterized. However, the function of GPIX is still elusive. To obtain further information of GPIX, we have determined a cDNA sequence of mouse GPIX (811 bp). The deduced amino- acid sequence (177aa) was 71% identical to the human GPIX protein. All cysteine residues in extracytoplasmic domain and putative N-linked glycosylation site (Asn44) were conserved. Mouse GPIX contained a leucine- rich glycoprotein sequence composed of 24 amino acids, as did human GPIX.

元の言語English
ページ(範囲)381-385
ページ数5
ジャーナルBlood Coagulation and Fibrinolysis
9
発行部数4
出版物ステータスPublished - 1998
外部発表Yes

ASJC Scopus subject areas

  • Hematology

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    Kitaguchi, T., Murata, M., Ambo, H., & Ikeda, Y. (1998). Characterization of cDNA encoding full-length mouse platelet glycoprotein IX. Blood Coagulation and Fibrinolysis, 9(4), 381-385.