Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

Tsuyoshi Akagi, Hiroaki Ono, Hiroshi Nyunoya, Kunitada Shimotohno

研究成果: Article

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Tax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-κB, and SRF. This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I. To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors. Analysis of these PBLs revealed that activation of the NF-κB pathway is sufficient to promote the growth response to IL-2. However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required.

元の言語English
ページ(範囲)2071-2078
ページ数8
ジャーナルOncogene
14
発行部数17
DOI
出版物ステータスPublished - 1997 1 1
外部発表Yes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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