Characterization of reactive oxygen species generated by protoporphyrin IX under X-ray irradiation

Junko Takahashi, Masaki Misawa*

*この研究の対応する著者

研究成果: Article査読

40 被引用数 (Scopus)

抄録

As a possible radiosensitizer candidate having biological compatibility, oncotropic property, and X-ray activation capability, contribution of protoporphyrin IX (PpIX) to enhanced generation of reactive oxygen species (ROS) under X-ray and UV irradiations were examined. To identify the kinds of ROS, 2-[6-(4-amino)phenoxy-3H-xanthen-3-on-9-yl] benzoic acid (APF) and dihydroethidium (DHE) were used together with ethanol as a hydroxyl radical (OH{radical dot}) quencher. All of the three species of our interest (OH{radical dot}, superoxide radical (O2{radical dot}-), and singlet oxygen (1O2)) were enhanced by PpIX under X-ray and UV irradiations in addition to those by radiolysis and photolysis. Its enhancement factors exceeded 1.7 depending on the concentrations of PpIX from 1.5 to 15.0 μg/ml.

本文言語English
ページ(範囲)889-898
ページ数10
ジャーナルRadiation Physics and Chemistry
78
11
DOI
出版ステータスPublished - 2009 11月
外部発表はい

ASJC Scopus subject areas

  • 放射線

フィンガープリント

「Characterization of reactive oxygen species generated by protoporphyrin IX under X-ray irradiation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル