Charged polymers via controlled radical polymerization and their implications for gene delivery

William H. Heath, Askim F. Senyurt, John Layman, Timothy Edward Long*

*この研究の対応する著者

研究成果: Article査読

39 被引用数 (Scopus)

抄録

Non-viral gene delivery agents are notorious for their poor nucleic acid transfection efficiency and relatively high cell cytotoxicity. Thus, many investigators are exploring the important parameters involved in charged polymer-mediated gene delivery, such as chemical composition, molecular weight, structural architecture, surface charge, etc. It is important to develop clear structure-property relationships in order to design successful nucleic acid delivery agents for gene therapy. To elucidate these relationships, well-defined materials are necessary. Controlled radical polymerization methods offer a facile route to systematically produce well-defined, structurally distinct gene delivery agents. The use of charged polymers prepared via controlled radical polymerizations to elucidate transfection mechanisms or develop new delivery vectors will be reviewed herein.

本文言語English
ページ(範囲)1243-1249
ページ数7
ジャーナルMacromolecular Chemistry and Physics
208
12
DOI
出版ステータスPublished - 2007 6月 19
外部発表はい

ASJC Scopus subject areas

  • 凝縮系物理学
  • 物理化学および理論化学
  • ポリマーおよびプラスチック
  • 有機化学
  • 材料化学

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