Chiral discrimination between thalidomide enantiomers using a solid surface with two-dimensional chirality

Takuya Nakanishi, Naoko Yamakawa, Toru Asahi, Norio Shibata, Bunsho Ohtani, Tetsuya Osaka

研究成果: Article

36 引用 (Scopus)

抜粋

Chiral discrimination between thalidomide enantiomers was achieved using the self-assembled monolayer (SAM) of an atropisomeric compound, 1,1′-binaphthalene-2,2′-dithiol (BNSH), which takes a two-dimensional chiral arrangement on gold(111) surface. Interestingly, an "all-or-none" type enantioselectivity appears; one enantiomeric form of BNSH SAM allows the adsorption of only one enantiomer of thalidomide. In addition, the response of a racemic SAM of BNSH was revealed to be one-alf of that caused by pure enantiomeric SAM.

元の言語English
ページ(範囲)S36-S39
ジャーナルChirality
16
発行部数SUPPL.
DOI
出版物ステータスPublished - 2004 8 3

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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