Chiral discrimination between thalidomide enantiomers using a solid surface with two-dimensional chirality

Takuya Nakanishi*, Naoko Yamakawa, Toru Asahi, Norio Shibata, Bunsho Ohtani, Tetsuya Osaka

*この研究の対応する著者

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Chiral discrimination between thalidomide enantiomers was achieved using the self-assembled monolayer (SAM) of an atropisomeric compound, 1,1′-binaphthalene-2,2′-dithiol (BNSH), which takes a two-dimensional chiral arrangement on gold(111) surface. Interestingly, an "all-or-none" type enantioselectivity appears; one enantiomeric form of BNSH SAM allows the adsorption of only one enantiomer of thalidomide. In addition, the response of a racemic SAM of BNSH was revealed to be one-alf of that caused by pure enantiomeric SAM.

本文言語English
ページ(範囲)S36-S39
ジャーナルChirality
16
SUPPL.
DOI
出版ステータスPublished - 2004 8月 3

ASJC Scopus subject areas

  • 分析化学
  • 触媒
  • 薬理学
  • 創薬
  • 分光学
  • 有機化学

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