TY - JOUR
T1 - Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis
AU - Taniguchi, Kiichiro
AU - Maeda, Reo
AU - Ando, Tadashi
AU - Okumura, Takashi
AU - Nakazawa, Naotaka
AU - Hatori, Ryo
AU - Nakamura, Mitsutoshi
AU - Hozumi, Shunya
AU - Fujiwara, Hiroo
AU - Matsuno, Kenji
PY - 2011/7/15
Y1 - 2011/7/15
N2 - Some organs in animals display left-right (LR) asymmetry. To better understand LR asymmetric morphogenesis in Drosophila, we studied LR directional rotation of the hindgut epithelial tube. Hindgut epithelial cells adopt a LR asymmetric (chiral) cell shape within their plane, and we refer to this cell behavior as planar cell-shape chirality (PCC). Drosophila E-cadherin (DE-Cad) is distributed to cell boundaries with LR asymmetry, which is responsible for the PCC formation. Myosin ID switches the LR polarity found in PCC and in DE-Cad distribution, which coincides with the direction of rotation. An in silico simulation showed that PCC is sufficient to induce the directional rotation of this tissue. Thus, the intrinsic chirality of epithelial cells in vivo is an underlying mechanism for LR asymmetric tissue morphogenesis.
AB - Some organs in animals display left-right (LR) asymmetry. To better understand LR asymmetric morphogenesis in Drosophila, we studied LR directional rotation of the hindgut epithelial tube. Hindgut epithelial cells adopt a LR asymmetric (chiral) cell shape within their plane, and we refer to this cell behavior as planar cell-shape chirality (PCC). Drosophila E-cadherin (DE-Cad) is distributed to cell boundaries with LR asymmetry, which is responsible for the PCC formation. Myosin ID switches the LR polarity found in PCC and in DE-Cad distribution, which coincides with the direction of rotation. An in silico simulation showed that PCC is sufficient to induce the directional rotation of this tissue. Thus, the intrinsic chirality of epithelial cells in vivo is an underlying mechanism for LR asymmetric tissue morphogenesis.
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U2 - 10.1126/science.1200940
DO - 10.1126/science.1200940
M3 - Article
C2 - 21764746
AN - SCOPUS:79960550299
SN - 0036-8075
VL - 333
SP - 339
EP - 341
JO - Science
JF - Science
IS - 6040
ER -