Cipralphelin, a new anti-oxidative N-cinnamoyl tripeptide produced by the deep sea-derived fungal strain Penicillium brevicompactum FKJ-0123

Hirotaka Matsuo, Takayuki Mokudai, Mayuka Higo, Kenichi Nonaka, Yuriko Nagano, Takahiko Nagahama, Yoshimi Niwano, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima*

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

A new N-cinnamoyl tripeptide, designated cipralphelin (1), was isolated from a cultured broth of Penicillium brevicompactum FKJ-0123 by physicochemical (PC) screening. Compound 1 was purified by silica gel and ODS column chromatography followed by preparative HPLC. The structure of 1 was determined as N-cinnamoyl-prolyl-alanyl-phenylalanine methyl ester by nuclear magnetic resonance and mass spectrometry analyses. The absolute configurations of three amino acids were determined by an advanced Marfey’s method applied to the hydrolysate of 1. Compound 1 was evaluated for its cytotoxicity, anti-microbial activity, and ability to scavenge or quench reactive oxygen species (ROS) such as superoxide anion radicals, hydroxy radicals, and singlet oxygen. Compound 1 exhibited potent scavenging activity against hydroxy radicals.

本文言語English
ページ(範囲)775-778
ページ数4
ジャーナルJournal of Antibiotics
72
10
DOI
出版ステータスPublished - 2019 10月 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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