Circadian changes in long-term potentiation of rat suprachiasmatic field potentials elicited by optic nerve stimulation in vitro

Yukiko Nishikawa, Shigenobu Shibata, Shigenori Watanabe

研究成果: Article

30 引用 (Scopus)

抄録

Optic nerve stimulation caused a postsynaptic field potential in the rat suprachiasmatic nucleus (SCN) of hypothalamic slices. In the present experiment, we demonstrated whether tetanic stimulation of optic nerve can produce a long-term potentiation (LTP) in the SCN postsynaptic field potential. The amplitude of SCN field potential was higher in the subjective day animals than that in the subjective night animals. Tetanic stimulation of optic nerve (100 Hz, 1 s) at subjective daytime (projected zeitgeber time: ZT 0-8) produced a LTP in this field potential, although the onset of LTP was slow. When tetanic stimulation was applied at ZT4, the percent increase of amplitude was 116.6% immediately after, 159.8% 30 min after and 215.4% 120 min after tetanic stimulation, whereas tetanic stimulation of optic nerve at subjective night-time caused a weak LTP in the SCN. Although tetanic stimulation of Schaffer collaterals induced a LTP formation in the CA1 region of rat hippocampal slices, there were no obvious circadian changes in this LTP formation. The present results demonstrated that excitatory influence on the SCN caused a synaptic plasticity such as LTP. Although the physiological meaning of this LTP is uncertain at present, LTP may be related to adaptation mechanism to photic stimulation.

元の言語English
ページ(範囲)158-162
ページ数5
ジャーナルBrain Research
695
発行部数2
DOI
出版物ステータスPublished - 1995 10 16
外部発表Yes

Fingerprint

Long-Term Potentiation
Optic Nerve
Suprachiasmatic Nucleus
Synaptic Potentials
Hippocampal CA1 Region
In Vitro Techniques
Photic Stimulation
Neuronal Plasticity
Hippocampus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

これを引用

Circadian changes in long-term potentiation of rat suprachiasmatic field potentials elicited by optic nerve stimulation in vitro. / Nishikawa, Yukiko; Shibata, Shigenobu; Watanabe, Shigenori.

:: Brain Research, 巻 695, 番号 2, 16.10.1995, p. 158-162.

研究成果: Article

@article{370f515cfdbd421f9a37de0c966859ca,
title = "Circadian changes in long-term potentiation of rat suprachiasmatic field potentials elicited by optic nerve stimulation in vitro",
abstract = "Optic nerve stimulation caused a postsynaptic field potential in the rat suprachiasmatic nucleus (SCN) of hypothalamic slices. In the present experiment, we demonstrated whether tetanic stimulation of optic nerve can produce a long-term potentiation (LTP) in the SCN postsynaptic field potential. The amplitude of SCN field potential was higher in the subjective day animals than that in the subjective night animals. Tetanic stimulation of optic nerve (100 Hz, 1 s) at subjective daytime (projected zeitgeber time: ZT 0-8) produced a LTP in this field potential, although the onset of LTP was slow. When tetanic stimulation was applied at ZT4, the percent increase of amplitude was 116.6{\%} immediately after, 159.8{\%} 30 min after and 215.4{\%} 120 min after tetanic stimulation, whereas tetanic stimulation of optic nerve at subjective night-time caused a weak LTP in the SCN. Although tetanic stimulation of Schaffer collaterals induced a LTP formation in the CA1 region of rat hippocampal slices, there were no obvious circadian changes in this LTP formation. The present results demonstrated that excitatory influence on the SCN caused a synaptic plasticity such as LTP. Although the physiological meaning of this LTP is uncertain at present, LTP may be related to adaptation mechanism to photic stimulation.",
keywords = "Circadian rhythm, Field potential, Long-term potentiation, Suprachiasmatic nucleus",
author = "Yukiko Nishikawa and Shigenobu Shibata and Shigenori Watanabe",
year = "1995",
month = "10",
day = "16",
doi = "10.1016/0006-8993(95)00717-5",
language = "English",
volume = "695",
pages = "158--162",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Circadian changes in long-term potentiation of rat suprachiasmatic field potentials elicited by optic nerve stimulation in vitro

AU - Nishikawa, Yukiko

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

PY - 1995/10/16

Y1 - 1995/10/16

N2 - Optic nerve stimulation caused a postsynaptic field potential in the rat suprachiasmatic nucleus (SCN) of hypothalamic slices. In the present experiment, we demonstrated whether tetanic stimulation of optic nerve can produce a long-term potentiation (LTP) in the SCN postsynaptic field potential. The amplitude of SCN field potential was higher in the subjective day animals than that in the subjective night animals. Tetanic stimulation of optic nerve (100 Hz, 1 s) at subjective daytime (projected zeitgeber time: ZT 0-8) produced a LTP in this field potential, although the onset of LTP was slow. When tetanic stimulation was applied at ZT4, the percent increase of amplitude was 116.6% immediately after, 159.8% 30 min after and 215.4% 120 min after tetanic stimulation, whereas tetanic stimulation of optic nerve at subjective night-time caused a weak LTP in the SCN. Although tetanic stimulation of Schaffer collaterals induced a LTP formation in the CA1 region of rat hippocampal slices, there were no obvious circadian changes in this LTP formation. The present results demonstrated that excitatory influence on the SCN caused a synaptic plasticity such as LTP. Although the physiological meaning of this LTP is uncertain at present, LTP may be related to adaptation mechanism to photic stimulation.

AB - Optic nerve stimulation caused a postsynaptic field potential in the rat suprachiasmatic nucleus (SCN) of hypothalamic slices. In the present experiment, we demonstrated whether tetanic stimulation of optic nerve can produce a long-term potentiation (LTP) in the SCN postsynaptic field potential. The amplitude of SCN field potential was higher in the subjective day animals than that in the subjective night animals. Tetanic stimulation of optic nerve (100 Hz, 1 s) at subjective daytime (projected zeitgeber time: ZT 0-8) produced a LTP in this field potential, although the onset of LTP was slow. When tetanic stimulation was applied at ZT4, the percent increase of amplitude was 116.6% immediately after, 159.8% 30 min after and 215.4% 120 min after tetanic stimulation, whereas tetanic stimulation of optic nerve at subjective night-time caused a weak LTP in the SCN. Although tetanic stimulation of Schaffer collaterals induced a LTP formation in the CA1 region of rat hippocampal slices, there were no obvious circadian changes in this LTP formation. The present results demonstrated that excitatory influence on the SCN caused a synaptic plasticity such as LTP. Although the physiological meaning of this LTP is uncertain at present, LTP may be related to adaptation mechanism to photic stimulation.

KW - Circadian rhythm

KW - Field potential

KW - Long-term potentiation

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0028792170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028792170&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(95)00717-5

DO - 10.1016/0006-8993(95)00717-5

M3 - Article

C2 - 8556326

AN - SCOPUS:0028792170

VL - 695

SP - 158

EP - 162

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -