Circadian rhythm of spontaneous neuronal activity in the suprachiasmatic nucleus of old hamster in vitro

Akihito Watanabe, Shigenobu Shibata*, Shigenori Watanabe

*この研究の対応する著者

研究成果: Article査読

83 被引用数 (Scopus)

抄録

The effects of aging on neuronal activity in the suprachiasmatic nucleus (SCN) were examined in hamsters kept under light-dark (LD) or constant light (LL) conditions. The free-running period in wheel-running rhythm of 24-month-old hamsters (24.2 ± 0.04) was shorter than that of the 2-month-old hamsters (24.4 ± 0.057). There was a significant difference in the mean firing rates of SCN neuron activity between old and young hamster during subjective day (6.58 ± 0.36 spikes/s in young and 5.63 ± 0.24 in old hamsters), but not during subjective night (4.33 ± 0.47 in young and 4.05 ± 0.39 in old). Similar to LL condition, the firing activity during zeitgeber time 3-11 (4.33 ± 0.27) in old hamsters kept under LD condition, was significantly lower than that of young hamster (6.22 ± 0.32). These results suggest that deterioration of SCN neuronal activity in old hamsters assessed as reduction of daytime activity may reflect changes in the interaction between SCN clocks and the overt behaviors and/or pacemaking properties of SCN cells.

本文言語English
ページ(範囲)237-239
ページ数3
ジャーナルBrain Research
695
2
DOI
出版ステータスPublished - 1995 10月 16
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

フィンガープリント

「Circadian rhythm of spontaneous neuronal activity in the suprachiasmatic nucleus of old hamster in vitro」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル