Circulating endotoxin and inflammation: Associations with fitness, physical activity and the effect of a 6-month programme of cycling exercise during haemodialysis

Daniel S. March*, Ka Bik Lai, Tracy Neal, Matthew P.M. Graham-Brown, Patrick J. Highton, Darren R. Churchward, Hannah M.L. Young, Maurice Dungey, David J. Stensel, Alice C. Smith, Nicolette C. Bishop, Cheuk Chun Szeto, James O. Burton

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background: Intradialytic cycling (IDC) may provide cardiovascular benefits to individuals receiving haemodialysis, but the exact mechanism behind these improvements remains unclear. The primary aim of this study was to investigate the effect of a 6-month programme of IDC on circulating endotoxin (secondary analysis from the CYCLE-HD trial). Secondary aims were to investigate changes in circulating cytokines [interleukin-6 (IL-6), IL-10, tumour necrosis factor-α, C-reactive protein (CRP) and the IL-6:IL-10 ratio] and their associations with physical activity, fitness and cardiovascular outcomes. Methods: Participants were randomized to either a 6-month programme of IDC (thrice weekly, moderate intensity cycling at a rating of perceived exertion of 12-14) in addition to usual care (n = 46) or usual care only (control group; n = 46). Outcome measures were obtained at baseline and then again at 6 months. Results: There was no significant (P = 0.137) difference in circulating endotoxin between groups at 6 months (IDC group: 0.34 ± 0.08 EU/mL; control group: 0.37 ± 0.07 EU/mL). There were no significant between-group differences in any circulating cytokine following the 6-month programme of IDC. Higher levels of physical activity and fitness were associated with lower levels of endotoxin, IL-6, CRP and IL-6:IL-10 ratio. Conclusions: Our data show no change in circulating endotoxin or cytokines following a 6-month programme of IDC. However, higher levels of physical activity outside of haemodialysis were associated with lower levels of inflammation.

本文言語English
ページ(範囲)366-374
ページ数9
ジャーナルNephrology Dialysis Transplantation
37
2
DOI
出版ステータスPublished - 2022 2月 1
外部発表はい

ASJC Scopus subject areas

  • 腎臓病学
  • 移植

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