Claudin-21 has a paracellular channel role at tight junctions

Hiroo Tanaka, Yasuko Yamamoto, Hiroka Kashihara, Yuji Yamazaki, Kazutoshi Tani, Yoshinori Fujiyoshi, Katsuhiko Mineta, Kosei Takeuchi, Atsushi Tamura*, Sachiko Tsukita

*この研究の対応する著者

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Claudin protein family members, of which there are at least 27 in humans and mice, polymerize to form tight junctions (TJs) between epithelial cells, in a tissue- and developmental stage-specific manner. Claudins have a paracellular barrier function. In addition, certain claudins function as paracellular channels for small ions and/or solutes by forming selective pores at the TJs, although the specific claudins involved and their functional mechanisms are still in question. Here we show for the first time that claudin-21, which is more highly expressed in the embryonic than the postnatal stages, acts as a paracellular channel for small cations, such as Na+, similar to the typical channel-type claudins claudin-2 and -15. Claudin-21 also allows the paracellular passage of larger solutes. Our findings suggest that claudin-21-based TJs allow the passage of small and larger solutes by both paracellular channel-based and some additional mechanisms.

本文言語English
ページ(範囲)954-964
ページ数11
ジャーナルMolecular and Cellular Biology
36
6
DOI
出版ステータスPublished - 2016
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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