Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Yoh Ichi Matsushita, Kiyoshi Eshima, Takashi Shindo, Yoshio Yamamoto, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-14C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 ± 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.

本文言語English
ページ(範囲)166-171
ページ数6
ジャーナルBBA - Biomembranes
901
1
DOI
出版ステータスPublished - 1987 7 10

ASJC Scopus subject areas

  • 生化学
  • 生物理学
  • 細胞生物学
  • 医学(全般)

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