Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope

Harubumi Kato, Jutaro Ono, Chimori Konaka, Norihiko Kawate, Kazuo Yoneyama, Komei Kinoshita, Katsuaki Nishimiya, Harumasa Sakai, Masayuki Noguchi, Takahisa Tomono, Yoshihiro Hayata, Katsuo Aizawa, Satoru Kawasaki, Yasuaki Tokuda

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Hematoporphyrin derivative (HPD) is retained by malignant tumors and emits fluorescence with peaks of 630 and 690 nm wavelength when HPD is exposed to light. It is therefore theoretically possible to make a diagnosis of malignant tumors by detecting the fluorescence of HPD. The authors developed a spectroscope system compatible with fiberoptic endoscopes to analyze the shape of the fluorescence light spectrum. We could clearly recognize the HPD‐specific fluorescence in human cancer foci. This system can be applied to the measurement of the relative amount of HPD absorbed in superficial tumor tissue before the photodynamic therapy. This might suggest the extent of tumor. The clinical diagnostic applications of this system are described in this study.

本文言語English
ページ(範囲)49-58
ページ数10
ジャーナルLasers in Surgery and Medicine
4
1
DOI
出版ステータスPublished - 1984
外部発表はい

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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