Cloning and characterization of the promoter of murine cytohesin-1 gene

Nobuhito Goda, Akito Tanoue*, Shintaro Kikuchi, Gozoh Tsujimoto

*この研究の対応する著者

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Mouse cytohesin-1 (CTH-1) is a guanine nucleotide exchange factor, specific for ADP ribosylation factors. The CTH-1 gene promoter was characterized by deletion mapping and mutational analysis. The region between -101 and -38 relative to the transcription start site showed the essential promoter activity when transfected into both NIH3T3 and COS7 cells. The nucleotides of the core promoter region contain three tandem GC boxes, which can offer potential binding sites for the ubiquitous transcription factor Sp- 1 family. Mutational analysis revealed that these tandem GC boxes are indispensable for activation of the gene transcription. (C) 2000 Elsevier Science B.V.

本文言語English
ページ(範囲)195-199
ページ数5
ジャーナルBiochimica et Biophysica Acta - Gene Structure and Expression
1493
1-2
DOI
出版ステータスPublished - 2000 9月 7
外部発表はい

ASJC Scopus subject areas

  • 構造生物学
  • 生物理学
  • 生化学
  • 遺伝学

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