Co-ordinated functions of Mms proteins define the surface structure of cubo-octahedral magnetite crystals in magnetotactic bacteria

Atsushi Arakaki, Ayana Yamagishi, Ayumi Fukuyo, Masayoshi Tanaka, Tadashi Matsunaga*

*この研究の対応する著者

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Magnetotactic bacteria synthesize magnetosomes comprised of membrane-enveloped single crystalline magnetite (Fe3O4). The size and morphology of the nano-sized magnetite crystals (<100nm) are highly regulated and bacterial species dependent. However, the control mechanisms of magnetite crystal morphology remain largely unknown. The group of proteins, called Mms (Mms5, Mms6, Mms7, and Mms13), was previously isolated from the surface of cubo-octahedral magnetite crystals in Magnetospirillum magneticum strain AMB-1. Analysis of an mms6 gene deletion mutant suggested that the Mms6 protein plays a major role in the regulation of magnetite crystal size and morphology. In this study, we constructed various mms gene deletion mutants and characterized the magnetite crystals formed by the mutant strains. Comparative analysis showed that all mms genes were involved in the promotion of crystal growth in different manners. The phenotypic characterization of magnetites also suggested that these proteins are involved in controlling the geometries of the crystal surface structures. Thus, the co-ordinated functions of Mms proteins regulate the morphology of the cubo-octahedral magnetite crystals in magnetotactic bacteria.

本文言語English
ページ(範囲)554-567
ページ数14
ジャーナルMolecular Microbiology
93
3
DOI
出版ステータスPublished - 2014
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 微生物学
  • 医学(全般)

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