Collagen-like cell-penetrating peptides

Chisato M. Yamazaki, Ikuhiko Nakase, Hiroyuki Endo, Saya Kishimoto, Yoshihiro Mashiyama, Ryo Masuda, Shiroh Futaki, Takaki Koide

研究成果査読

33 被引用数 (Scopus)

抄録

Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.

本文言語English
ページ(範囲)5497-5500
ページ数4
ジャーナルAngewandte Chemie - International Edition
52
21
DOI
出版ステータスPublished - 2013 5 17

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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