Collagen-like triple helical peptides: Applications in drug development and regenerative medicine

    研究成果: Article査読

    2 被引用数 (Scopus)

    抄録

    Collagen family proteins are the predominant components of extracellular matrices existing in all multicellular animals. They provide mechanical strength to tissues, and maintain structural integrity of organs. Also, collagens regulate various biological events, including cell attachment, migration, tissue regeneration and animal development. The specific functions of collagens are generally elicited by interactions of collagen-binding molecules (membrane receptors, soluble factors and other matrix components) with certain amino acid sequences displayed on the collagen triple helices. To date, numbers of functional sequences have been identified from the triple helical domains. Collagen is also acknowledged as one of useful biomaterials in regenerative medicine and tissue engineering. In this review, I summarize challenges made for the development of safer and highly-functional collagen surrogates by means of self-assembly of synthetic collagen-like peptides. I also describe other possible applications of collagen-like peptides in drug delivery focusing on the particular biophysical properties of the triple helical structure.

    本文言語English
    ページ(範囲)387-392
    ページ数6
    ジャーナルYakugaku Zasshi
    133
    3
    DOI
    出版ステータスPublished - 2013

    ASJC Scopus subject areas

    • 薬理学
    • 薬科学

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