Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration

Naoya Yamashita, Yutaka Uchida, Toshio Ohshima, Syu Ichi Hirai, Fumio Nakamura, Masahiko Taniguchi, Katsuhiko Mikoshiba, Jérôme Honnorat, Pappachan Kolattukudy, Nicole Thomasset, Kohtaro Takei, Takuya Takahashi, Yoshio Goshima

研究成果: Article査読

64 被引用数 (Scopus)

抄録

Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that mediates signal transduction of axon guidance molecules. Here, we show evidence that CRMP1 is involved in Reelin (Reln) signaling to regulate neuronal migration in the cerebral cortex. In crmp1-/- mice, radial migration of cortical neurons was retarded. This phenotype was not observed in the sema3A-/- and crmp1+/-;sema3A+/- cortices. However, CRMP1 was colocalized with disabled-1 (Dab1), an adaptor protein in Reln signaling. In the Relnrl/rl cortex, CRMP1 and Dab1 were expressed at a higher level, yet tyrosine phosphorylated at a lower level. Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling.

本文言語English
ページ(範囲)13357-13362
ページ数6
ジャーナルJournal of Neuroscience
26
51
DOI
出版ステータスPublished - 2006 12 20
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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