Collective total synthesis of PPAPs: Total synthesis of clusianone via intramolecular cyclopropanation

Masahiro Uwamori, Masahisa Nakada

研究成果: Review article査読

9 被引用数 (Scopus)

抄録

The total synthesis of clusianone was accomplished through the stereoselective construction of a bicyclo[3.3.1]nonane derivative via a three-step sequence, which has been utilized for the total syntheses of nemorosone, garsubellin A, and hyperforin: intramolecular cyclopropanation, formation of a geminal dimethyl group, and regioselective ring opening of cyclopropane. Further elaboration, including chemo- And stereoselective hydrogenation to generate the C7 stereogenic center and cross-metathesis to construct prenyl groups in the side-chains, was employed to complete the total synthesis of clusianone.

本文言語English
ページ(範囲)955-959
ページ数5
ジャーナルNatural Product Communications
8
7
出版ステータスPublished - 2013 8 2

ASJC Scopus subject areas

  • 薬理学
  • 植物科学
  • 創薬
  • 補完代替医療

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