Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery

Hongen Liao, Koji Shimaya, Kaimeng Wang, Takashi Maruyama, Masafumi Noguchi, Yoshihiro Muragaki, Etsuko Kobayashi, Hiroshi Iseki, Ichiro Sakuma

    研究成果: Conference contribution

    18 引用 (Scopus)

    抜粋

    A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.

    元の言語English
    ホスト出版物のタイトルMedical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
    ページ373-380
    ページ数8
    エディションPART 2
    DOI
    出版物ステータスPublished - 2008 12 1
    イベント11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008 - New York, NY, United States
    継続期間: 2008 9 62008 9 10

    出版物シリーズ

    名前Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    番号PART 2
    5242 LNCS
    ISSN(印刷物)0302-9743
    ISSN(電子版)1611-3349

    Conference

    Conference11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
    United States
    New York, NY
    期間08/9/608/9/10

      フィンガープリント

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

    これを引用

    Liao, H., Shimaya, K., Wang, K., Maruyama, T., Noguchi, M., Muragaki, Y., Kobayashi, E., Iseki, H., & Sakuma, I. (2008). Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. : Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings (PART 2 版, pp. 373-380). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 巻数 5242 LNCS, 番号 PART 2). https://doi.org/10.1007/978-3-540-85990-1-45