抄録
The mammalian Y chromosome has unique characteristics compared with the autosomes or X chromosomes. Here we report the finished sequence of the chimpanzee Y chromosome (PTRY), including 271 kb of the Y-specific pseudoautosomal region 1 and 12.7 Mb of the male-specific region of the Y chromosome. Greater sequence divergence between the human Y chromosome (HSAY) and PTRY (1.78%) than between their respective whole genomes (1.23%) confirmed the accelerated evolutionary rate of the Y chromosome. Each of the 19 PTRY protein-coding genes analyzed had at least one nonsynonymous substitution, and 11 genes had higher nonsynonymous substitution rates than synonymous ones, suggesting relaxation of selective constraint, positive selection or both. We also identified lineage-specific changes, including deletion of a 200-kb fragment from the pericentromeric region of HSAY, expansion of young Alu families in HSAY and accumulation of young L1 elements and long terminal repeat retrotransposons in PTRY. Reconstruction of the common ancestral Y chromosome reflects the dynamic changes in our genomes in the 5-6 million years since speciation.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 1-10 |
| ページ数 | 10 |
| ジャーナル | Nature Genetics |
| 巻 | 38 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 2006 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Genetics
これを引用
Comparative analysis of chimpanzee and human y chromosomes unveils complex evolutionary pathway. / Kuroki, Yoko; Toyoda, Atsushi; Noguchi, Hideki; Taylor, Todd D.; Itoh, Takehiko; Kim, Dae Soo; Kim, Dae Won; Choi, Sang Haeng; Kim, Il Chul; Choi, Han Ho; Kim, Yong Sung; Satta, Yoko; Saitou, Naruya; Yamada, Tomoyuki; Morishita, Shinichi; Hattori, Masahira; Sakaki, Yoshiyuki; Park, Hong Seog; Fujiyama, Asao.
：: Nature Genetics, 巻 38, 番号 2, 2006, p. 1-10.研究成果: Article
}
TY - JOUR
T1 - Comparative analysis of chimpanzee and human y chromosomes unveils complex evolutionary pathway
AU - Kuroki, Yoko
AU - Toyoda, Atsushi
AU - Noguchi, Hideki
AU - Taylor, Todd D.
AU - Itoh, Takehiko
AU - Kim, Dae Soo
AU - Kim, Dae Won
AU - Choi, Sang Haeng
AU - Kim, Il Chul
AU - Choi, Han Ho
AU - Kim, Yong Sung
AU - Satta, Yoko
AU - Saitou, Naruya
AU - Yamada, Tomoyuki
AU - Morishita, Shinichi
AU - Hattori, Masahira
AU - Sakaki, Yoshiyuki
AU - Park, Hong Seog
AU - Fujiyama, Asao
PY - 2006
Y1 - 2006
N2 - The mammalian Y chromosome has unique characteristics compared with the autosomes or X chromosomes. Here we report the finished sequence of the chimpanzee Y chromosome (PTRY), including 271 kb of the Y-specific pseudoautosomal region 1 and 12.7 Mb of the male-specific region of the Y chromosome. Greater sequence divergence between the human Y chromosome (HSAY) and PTRY (1.78%) than between their respective whole genomes (1.23%) confirmed the accelerated evolutionary rate of the Y chromosome. Each of the 19 PTRY protein-coding genes analyzed had at least one nonsynonymous substitution, and 11 genes had higher nonsynonymous substitution rates than synonymous ones, suggesting relaxation of selective constraint, positive selection or both. We also identified lineage-specific changes, including deletion of a 200-kb fragment from the pericentromeric region of HSAY, expansion of young Alu families in HSAY and accumulation of young L1 elements and long terminal repeat retrotransposons in PTRY. Reconstruction of the common ancestral Y chromosome reflects the dynamic changes in our genomes in the 5-6 million years since speciation.
AB - The mammalian Y chromosome has unique characteristics compared with the autosomes or X chromosomes. Here we report the finished sequence of the chimpanzee Y chromosome (PTRY), including 271 kb of the Y-specific pseudoautosomal region 1 and 12.7 Mb of the male-specific region of the Y chromosome. Greater sequence divergence between the human Y chromosome (HSAY) and PTRY (1.78%) than between their respective whole genomes (1.23%) confirmed the accelerated evolutionary rate of the Y chromosome. Each of the 19 PTRY protein-coding genes analyzed had at least one nonsynonymous substitution, and 11 genes had higher nonsynonymous substitution rates than synonymous ones, suggesting relaxation of selective constraint, positive selection or both. We also identified lineage-specific changes, including deletion of a 200-kb fragment from the pericentromeric region of HSAY, expansion of young Alu families in HSAY and accumulation of young L1 elements and long terminal repeat retrotransposons in PTRY. Reconstruction of the common ancestral Y chromosome reflects the dynamic changes in our genomes in the 5-6 million years since speciation.
UR - http://www.scopus.com/inward/record.url?scp=84984761809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84984761809&partnerID=8YFLogxK
U2 - 10.1038/ng1729
DO - 10.1038/ng1729
M3 - Article
C2 - 16388311
AN - SCOPUS:84984761809
VL - 38
SP - 1
EP - 10
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 2
ER -