Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA

Mutsunori Shirai*, Hideki Hirakawa, Mitsuaki Kimoto, Mitsuaki Tabuchi, Fumio Kishi, Kazunobu Ouchi, Tadayoshi Shiba, Kazuo Ishii, Masahira Hattori, Satoru Kuhara, Teruko Nakazawa

*この研究の対応する著者

研究成果: Article査読

146 被引用数 (Scopus)

抄録

Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C. pneumoniae infection and atherosclerosis. We determined the whole genome sequence of C. pneumoniae strain J138 isolated in Japan in 1994 and compared it with the sequence of strain CWL029 isolated in the USA before 1987. The J138 circular chromosome consists of 1,226,565 nt (40.7% G + C) with 1072 likely protein-coding genes that is 3665 nt shorter than the CWL029 genome. Plasmids, phage- or transposon-like sequences were not identified. The overall genomic organization, gene order and predicted proteomes of the two strains are very similar, suggesting a high level of structural and functional conservation between the two unrelated isolates. The most conspicuous differences in the J138 genome relative to the CWL029 genome are the absence of five DNA segments, ranging in size from 89 to 1649 nt, and the presence of three DNA segments, ranging from 27 to 84 nt. The complex organization of these 'different zones' may be attributable to a unique system of recombination.

本文言語English
ページ(範囲)2311-2314
ページ数4
ジャーナルNucleic Acids Research
28
12
出版ステータスPublished - 2000 6月 15
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

フィンガープリント

「Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル