Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen

Takatsugu Goto, Atsushi Yamashita, Hideki Hirakawa, Minenosuke Matsutani, Kozo Todo, Kenshiro Ohshima, Hidehiro Toh, Kazuaki Miyamoto, Satoru Kuhara, Masahira Hattori, Tohru Shimizu, Shigeru Akimoto

研究成果: Article

26 被引用数 (Scopus)

抄録

Finegoldia magna (formerly Peptostreptococcus mtagnus), a member of the Gram-positive anaerobic cocci (GPAC), is a commensal bacterium colonizing human skin and mucous membranes. Moreover, it is also recognized as an opportunistic pathogen responsible for various infectious diseases. Here, we report the complete genome sequence of F. magna ATCC 29328. The genome consists of a 1 797 577 bp circular chromosome and an 189 163 bp plasmid (pPEP1). The metabolic maps constructed based on the genome information confirmed that most F. magna strains cannot ferment most sugars, except fructose, and have various aminopeptidase activities. Three homologs of albumin-binding protein, a known virulence factor useful for antiphagocytosis, are encoded on the chromosome, and one albumin-binding protein homolog is encoded on the plasmid. A unique feature of the genome is that F. magna encodes many sortase genes, of which substrates may be involved in bacterial pathogen-esis, such as antiphagocytosis and adherence to the host cell. The plasmid pPEP1 encodes seven sortase and seven substrate genes, whereas the chromosome encodes four sortase and 19 substrate genes. These plasmid-encoded sortases may play important roles in the pathogenesis of F. magna by enriching the variety of cell wall anchored surface proteins.

本文言語English
ページ(範囲)39-47
ページ数9
ジャーナルDNA Research
15
1
DOI
出版ステータスPublished - 2008
外部発表はい

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Medicine(all)

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