Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation

Tulika Prakash, Kenshiro Oshima, Hidetoshi Morita, Shinji Fukuda, Akemi Imaoka, Naveen Kumar, Vineet K. Sharma, Seok Won Kim, Mahoko Takahashi, Naruya Saitou, Todd D. Taylor, Hiroshi Ohno, Yoshinori Umesaki, Masahira Hattori

研究成果: Article

75 引用 (Scopus)

抄録

Segmented filamentous bacteria (SFB) are noncultivable commensals inhabiting the gut of various vertebrate species and have been shown to induce Th17 cells in mice. We present the complete genome sequences of both rat and mouse SFB isolated from SFB-monocolonized hosts. The rat and mouse SFB genomes each harbor a single circular chromosome of 1.52 and 1.59 Mb encoding 1346 and 1420 protein-coding genes, respectively. The overall nucleotide identity between the two genomes is 86%, and the substitution rate was estimated to be similar to that of the free-living E. coli. SFB genomes encode typical genes for anaerobic fermentation and spore and flagella formation, but lack most of the amino acid biosynthesis enzymes, reminiscent of pathogenic Clostridia, exhibiting large dependency on the host. However, SFB lack most of the clostridial virulence-related genes. Comparative analysis with clostridial genomes suggested possible mechanisms for host responses and specific adaptations in the intestine.

元の言語English
ページ(範囲)273-284
ページ数12
ジャーナルCell Host and Microbe
10
発行部数3
DOI
出版物ステータスPublished - 2011 9 15
外部発表Yes

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Th17 Cells
Helper-Inducer T-Lymphocytes
Cell Differentiation
Genome
Bacteria
Flagella
Clostridium
Spores
Genes
Fermentation
Intestines
Virulence
Vertebrates
Nucleotides
Chromosomes
Escherichia coli
Amino Acids
Enzymes
Proteins

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

これを引用

Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation. / Prakash, Tulika; Oshima, Kenshiro; Morita, Hidetoshi; Fukuda, Shinji; Imaoka, Akemi; Kumar, Naveen; Sharma, Vineet K.; Kim, Seok Won; Takahashi, Mahoko; Saitou, Naruya; Taylor, Todd D.; Ohno, Hiroshi; Umesaki, Yoshinori; Hattori, Masahira.

:: Cell Host and Microbe, 巻 10, 番号 3, 15.09.2011, p. 273-284.

研究成果: Article

Prakash, T, Oshima, K, Morita, H, Fukuda, S, Imaoka, A, Kumar, N, Sharma, VK, Kim, SW, Takahashi, M, Saitou, N, Taylor, TD, Ohno, H, Umesaki, Y & Hattori, M 2011, 'Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation', Cell Host and Microbe, 巻. 10, 番号 3, pp. 273-284. https://doi.org/10.1016/j.chom.2011.08.007
Prakash, Tulika ; Oshima, Kenshiro ; Morita, Hidetoshi ; Fukuda, Shinji ; Imaoka, Akemi ; Kumar, Naveen ; Sharma, Vineet K. ; Kim, Seok Won ; Takahashi, Mahoko ; Saitou, Naruya ; Taylor, Todd D. ; Ohno, Hiroshi ; Umesaki, Yoshinori ; Hattori, Masahira. / Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation. :: Cell Host and Microbe. 2011 ; 巻 10, 番号 3. pp. 273-284.
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