Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan

Shizuo Kayama, Norifumi Shigemoto, Ryuichi Kuwahara, Kenshiro Oshima, Hideki Hirakawa, Junzo Hisatsune, Thomas Jové, Hisaaki Nishio, Katsutoshi Yamasaki, Yasunao Wada, Takeshi Ueshimo, Tetsuya Miura, Taijiro Sueda, Makoto Onodera, Michiya Yokozaki, Masahira Hattori, Hiroki Ohge, Motoyuki Sugai*

*この研究の対応する著者

研究成果: Article査読

27 被引用数 (Scopus)

抄録

We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.

本文言語English
ページ(範囲)1356-1359
ページ数4
ジャーナルAntimicrobial Agents and Chemotherapy
59
2
DOI
出版ステータスPublished - 2015 2月 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学(医学)
  • 薬理学
  • 感染症

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