Computer-aided design of hollow-fiber dialyzers

Y. Suzuki, F. Kohori, K. Sakai*

*この研究の対応する著者

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Blood and dialysate flow patterns in hollow-fiber dialyzers are complicated, and hence the flow patterns and mass transfer are difficult to analyze theoretically. Consequently, dialyzers are usually developed by a trial-and-error method. We attempt to design dialyzers by computer simulation analysis in this work. Blood-side and dialysate-side flows were modeled using the Hagen-Poiseuille equation and the Blake-Kozeny equation, respectively. These flow patterns were evaluated as pressure drop and velocity distribution. The mass transfer rate was evaluated as solute clearance. Computed values of the pressure drops and clearance for urea and vitamin B12 were found to agree closely with those obtained experimentally. We evaluated the influences of the inner diameter of hollow fibers, module geometry, and void fraction on the pressure drop and clearance, and computer-aided design was performed.

本文言語English
ページ(範囲)326-330
ページ数5
ジャーナルJournal of Artificial Organs
4
4
DOI
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • 医学(その他)
  • 生体材料
  • 生体医工学
  • 循環器および心血管医学

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