Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction

Tatsuya Nakamura, Mio Harachi, Takaaki Kano, Yuki Mukaeda, Seijiro Hosokawa

    研究成果: Article

    14 引用 (Scopus)

    抄録

    A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukaiyama aldol reaction and regio- and stereoselective reduction reactions. All isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.

    元の言語English
    ページ(範囲)3170-3173
    ページ数4
    ジャーナルOrganic Letters
    15
    発行部数12
    DOI
    出版物ステータスPublished - 2013 6 21

    Fingerprint

    Propionates
    Antimalarials
    synthesis
    Isomers
    isomers
    methodology
    3-hydroxybutanal

    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

    これを引用

    Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction. / Nakamura, Tatsuya; Harachi, Mio; Kano, Takaaki; Mukaeda, Yuki; Hosokawa, Seijiro.

    :: Organic Letters, 巻 15, 番号 12, 21.06.2013, p. 3170-3173.

    研究成果: Article

    Nakamura, Tatsuya ; Harachi, Mio ; Kano, Takaaki ; Mukaeda, Yuki ; Hosokawa, Seijiro. / Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction. :: Organic Letters. 2013 ; 巻 15, 番号 12. pp. 3170-3173.
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