Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction

Tatsuya Nakamura, Mio Harachi, Takaaki Kano, Yuki Mukaeda, Seijiro Hosokawa*

*この研究の対応する著者

研究成果: Article査読

17 被引用数 (Scopus)

抄録

A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukaiyama aldol reaction and regio- and stereoselective reduction reactions. All isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.

本文言語English
ページ(範囲)3170-3173
ページ数4
ジャーナルOrganic Letters
15
12
DOI
出版ステータスPublished - 2013 6 21

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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