Concurrent blockade of β-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 region

Masako Kobayashi, Masuo Ohno, Shigenobu Shibata, Tsuneyuki Yamamoto, Shigenori Watanabe

研究成果: Article

22 被引用数 (Scopus)

抄録

The muscarinic acetylcholine receptor antagonist scopolamine, but not the β-adrenoceptor antagonist propranolol or atenolol, suppressed tetanus- induced long-term potentiation (LTP) of population spikes in the rat hippocampal CA1 region. When scopolamine was coapplied with propranolol or atenolol, a synergistic effect in preventing LTP generation was observed. On the other hand, the coapplication of scopolamine and atenolol failed to affect tetanus-induced LTP of field EPSP. These findings suggest that cooperative mechanisms via muscarnic and β-adrenergic receptor activation might contribute to LTP induction in terms of the EPSP-spike potentiation, i.e., an increase in the excitability of hippocampal CA1 pyramidal cells after tetanic stimulation, but are independent of the tetanus-evoked potentiation of a suynaptic component.

本文言語English
ページ(範囲)242-246
ページ数5
ジャーナルBrain Research
777
1-2
DOI
出版ステータスPublished - 1997 11 28

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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