Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice

Yutaka Kosaki, Shigeru Watanabe

研究成果: Article

11 引用 (Scopus)

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Oxytocin (OT) has been implicated in a variety of mammalian reproductive and social behaviors, and the use of intranasal OT for clinical purposes is on the rise. However, basic actions of OT, including the rewarding or reinforcing properties of the drug, are currently not fully understood. In this study, the authors investigated whether intranasally administered OT has different reinforcing properties for social and nonsocial stimuli and whether such effects are variable between male and female subjects. Conditioned social preference (CSP) and conditioned place preference (CPP) paradigms were used to examine social and nonsocial reinforcing properties of OT. In CSP, the presence of a same-sex unfamiliar conspecific was repeatedly paired with intranasal OT, while a different conspecific was associated with saline. The reinforcing effect of OT was assessed in a postconditioning choice test under a drug-free condition. In CPP, the 2 conspecifics were replaced with nonsocial black and white compartments. The authors found that intranasal OT (12 μg) in females supported the formation of CSP (Experiment 1) but not CPP (Experiment 3). Neither CSP (Experiment 2) nor CPP (Experiment 4) was formed in males. Extended conditioning with higher dose OT (36 μg), however, abolished the initial CSP in females and produced an aversion to the OT-paired stimulus mouse. Experiment 5 indicated that it was the repeated administrations rather than the higher dose that produced the abolition of the original preference. Overall, the current results demonstrate for the first time a sex- and stimulus-dependent reinforcing property of intranasal OT in mice.

元の言語English
ページ(範囲)182-195
ページ数14
ジャーナルBehavioral Neuroscience
130
発行部数2
DOI
出版物ステータスPublished - 2016 4 1
外部発表Yes

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Oxytocin
Reproductive Behavior
Social Behavior
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Behavioral Neuroscience

これを引用

Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice. / Kosaki, Yutaka; Watanabe, Shigeru.

:: Behavioral Neuroscience, 巻 130, 番号 2, 01.04.2016, p. 182-195.

研究成果: Article

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