Construction and analysis of a human-chimpanzee comparative clone map

Asao Fujiyama, Hidemi Watanabe, Atsushi Toyoda, Todd D. Taylor, Takehiko Itoh, Shih Feng Tsai, Hong Seog Park, Marie Laure Yaspo, Hans Lehrach, Zhu Chen, Gang Fu, Naruya Saitou, Kazutoyo Osoegawa, Pieter J. De Jong, Yumiko Suto, Masahira Hattori, Yoshiyuki Sakaki

研究成果: Article

184 引用 (Scopus)

抜粋

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

元の言語English
ページ(範囲)131-134
ページ数4
ジャーナルScience
295
発行部数5552
DOI
出版物ステータスPublished - 2002 1 4
外部発表Yes

ASJC Scopus subject areas

  • General

フィンガープリント Construction and analysis of a human-chimpanzee comparative clone map' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Fujiyama, A., Watanabe, H., Toyoda, A., Taylor, T. D., Itoh, T., Tsai, S. F., Park, H. S., Yaspo, M. L., Lehrach, H., Chen, Z., Fu, G., Saitou, N., Osoegawa, K., De Jong, P. J., Suto, Y., Hattori, M., & Sakaki, Y. (2002). Construction and analysis of a human-chimpanzee comparative clone map. Science, 295(5552), 131-134. https://doi.org/10.1126/science.1065199