Construction of the taxane skeleton via the stereoselective conjugate addition of cyanide and the intramolecular B-alkyl Suzuki-Miyaura coupling reaction

Masayuki Utsugi, Yasuaki Kamada, Hidetoshi Miyamoto, Masahisa Nakada

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Construction of the taxane skeleton via the stereoselective conjugate addition of cyanide and the intramolecular B-alkyl Suzuki-Miyaura coupling reaction is described. A conjugate addition of cyanide to enone 17 proceeded diastereoselectively to provide the desired 18 incorporating the correct C3 stereogenic center in the taxol C-ring. The intramolecular B-alkyl Suzuki-Miyaura coupling reaction of 22, which was derived from 18, successfully furnished the taxol B-ring in 81% yield.

本文言語English
ページ(範囲)6868-6872
ページ数5
ジャーナルTetrahedron Letters
48
39
DOI
出版ステータスPublished - 2007 9 24

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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