Contractile system of muscle as an auto-oscillator

Shin'ichi Ishiwata*, Yuta Shimamoto, Norio Fukuda

*この研究の対応する著者

    研究成果: Article査読

    30 被引用数 (Scopus)

    抄録

    It is widely known that the contractile system of muscle takes on either the state of contraction (force-generating) or the state of relaxation (non-force-generating), which is known as the " all-or-nothing" principle. However, it is important to note that under intermediate activation conditions there exists a third state, which demonstrates auto-oscillatory properties and is termed SPOC (SPontaneous Oscillatory Contraction) state. We present a phase diagram, in which the states of the contractile system of muscle are divided into three regions consisting of contraction, relaxation and SPOC states. In the present review, experimental data related to the characteristics of SPOC are summarized and the mechanism of SPOC is described. We propose that the bio-motile system itself is an auto-oscillator, even in a membrane-less supra-molecular structure composed of an assembly of molecular motors and cytoskeletons (actin filaments and microtubules). Finally, the physiological significance of SPOC is discussed.

    本文言語English
    ページ(範囲)187-198
    ページ数12
    ジャーナルProgress in Biophysics and Molecular Biology
    105
    3
    DOI
    出版ステータスPublished - 2011 5月

    ASJC Scopus subject areas

    • 分子生物学
    • 生物理学

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