Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals

Hiroki Akiyama, Toru Matsu-Ura, Katsuhiko Mikoshiba, Hiroyuki Kamiguchi*

*この研究の対応する著者

研究成果: Article査読

39 被引用数 (Scopus)

抄録

Inositol 1,4,5-trisphosphate (IP3) is generally viewed as a global messenger that increases cytosolic calcium ion (Ca2+) concentration. However, the spatiotemporal dynamics of IP3 and the functional significance of localized IP3 production in cell polarity remain largely unknown. Here, we demonstrate the critical role of spatially restricted IP3 signals in axon guidance. We found that IP3 and ensuing Ca2+ signals were produced asymmetrically across growth cones exposed to an extracellular gradient of nerve growth factor (NGF) and mediated growth cone turning responses to NGF. Moreover, photolysisinduced production of IP3 on one side of a growth cone was sufficient to initiate growth cone turning toward the side with the higher concentration of IP3. Thus, locally produced IP3 encodes spatial information that polarizes the growth cone for guided migration.

本文言語English
ジャーナルScience Signaling
2
79
DOI
出版ステータスPublished - 2009 7月 14
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 細胞生物学
  • 分子生物学
  • 医学(全般)

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