Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Kohei Kubota, Hideo Kanazawa, Shuji Hisamoto, Shinji Takeoka

    研究成果: Conference contribution

    抄録

    Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

    元の言語English
    ホスト出版物のタイトルPolymer Preprints, Japan
    ページ2132
    ページ数1
    54
    エディション1
    出版物ステータスPublished - 2005
    イベント54th SPSJ Annual Meeting 2005 - Yokohama
    継続期間: 2005 5 252005 5 27

    Other

    Other54th SPSJ Annual Meeting 2005
    Yokohama
    期間05/5/2505/5/27

    Fingerprint

    Liposomes
    Lipids
    Polyethylene glycols
    Surface treatment
    Dispersions
    Hemodynamics
    Dilution
    Fusion reactions
    Agglomeration

    ASJC Scopus subject areas

    • Engineering(all)

    これを引用

    Kubota, K., Kanazawa, H., Hisamoto, S., & Takeoka, S. (2005). Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. : Polymer Preprints, Japan (1 版, 巻 54, pp. 2132)

    Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. / Kubota, Kohei; Kanazawa, Hideo; Hisamoto, Shuji; Takeoka, Shinji.

    Polymer Preprints, Japan. 巻 54 1. 編 2005. p. 2132.

    研究成果: Conference contribution

    Kubota, K, Kanazawa, H, Hisamoto, S & Takeoka, S 2005, Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. : Polymer Preprints, Japan. 1 Edn, 巻. 54, pp. 2132, 54th SPSJ Annual Meeting 2005, Yokohama, 05/5/25.
    Kubota K, Kanazawa H, Hisamoto S, Takeoka S. Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. : Polymer Preprints, Japan. 1 版 巻 54. 2005. p. 2132
    Kubota, Kohei ; Kanazawa, Hideo ; Hisamoto, Shuji ; Takeoka, Shinji. / Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. Polymer Preprints, Japan. 巻 54 1. 版 2005. pp. 2132
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    AU - Takeoka, Shinji

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