Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Kohei Kubota, Hideo Kanazawa, Shuji Hisamoto, Shinji Takeoka

研究成果: Paper

抜粋

Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

元の言語English
ページ数1
出版物ステータスPublished - 2005 12 1
イベント54th SPSJ Annual Meeting 2005 - Yokohama, Japan
継続期間: 2005 5 252005 5 27

Conference

Conference54th SPSJ Annual Meeting 2005
Japan
Yokohama
期間05/5/2505/5/27

ASJC Scopus subject areas

  • Engineering(all)

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  • これを引用

    Kubota, K., Kanazawa, H., Hisamoto, S., & Takeoka, S. (2005). Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, Japan.