抄録
Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.
| 元の言語 | English |
|---|---|
| ホスト出版物のタイトル | Polymer Preprints, Japan |
| ページ | 2132 |
| ページ数 | 1 |
| 巻 | 54 |
| エディション | 1 |
| 出版物ステータス | Published - 2005 |
| イベント | 54th SPSJ Annual Meeting 2005 - Yokohama 継続期間: 2005 5 25 → 2005 5 27 |
Other
| Other | 54th SPSJ Annual Meeting 2005 |
|---|---|
| 市 | Yokohama |
| 期間 | 05/5/25 → 05/5/27 |
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ASJC Scopus subject areas
- Engineering(all)
これを引用
Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. / Kubota, Kohei; Kanazawa, Hideo; Hisamoto, Shuji; Takeoka, Shinji.
Polymer Preprints, Japan. 巻 54 1. 編 2005. p. 2132.研究成果: Conference contribution
}
TY - GEN
T1 - Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances
AU - Kubota, Kohei
AU - Kanazawa, Hideo
AU - Hisamoto, Shuji
AU - Takeoka, Shinji
PY - 2005
Y1 - 2005
N2 - Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.
AB - Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.
KW - Hydrophilic-hydrophobic balance
KW - Liposome
KW - Multi alkyl chains
KW - Poly(ethylene glycol)-lipid
UR - http://www.scopus.com/inward/record.url?scp=33645645282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645645282&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33645645282
VL - 54
SP - 2132
BT - Polymer Preprints, Japan
ER -