TY - CONF
T1 - Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances
AU - Kubota, Kohei
AU - Kanazawa, Hideo
AU - Hisamoto, Shuji
AU - Takeoka, Shinji
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.
AB - Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.
KW - Hydrophilic-hydrophobic balance
KW - Liposome
KW - Multi alkyl chains
KW - Poly(ethylene glycol)-lipid
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M3 - Paper
AN - SCOPUS:33645645282
T2 - 54th SPSJ Annual Meeting 2005
Y2 - 25 May 2005 through 27 May 2005
ER -