抄録
Circadian rhythms, which are observed in most of living things, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period, and have the following properties: The first property is that the oscillation is entrained by light/dark cycles; the second one is that the oscillation, especially the period of the oscillation, is robust against changes of environment. In this paper, we investigate these two properties from control theoretic viewpoints. First, considering light/dark cycle as periodic control input, we try to explain how periodic control inputs can entrain one self-sustained circadian oscillator described by a core molecular model for Drosophila by Goldbeter (1995). Second, for structural understanding of robustness of circadian rhythms, we propose an evaluation method of the robustness based on period sensitivity, and try to design some rate parameters, which are regarded as control parameters, based on some optimizations using a robustness measure, when a rate parameter is moved to outside of normal area by environmental changes.
| 元の言語 | English |
|---|---|
| ホスト出版物のタイトル | Proceedings of the IEEE International Conference on Control Applications |
| ページ | 1740-1745 |
| ページ数 | 6 |
| DOI | |
| 出版物ステータス | Published - 2007 |
| イベント | Joint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC) - Munich 継続期間: 2006 10 4 → 2006 10 6 |
Other
| Other | Joint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC) |
|---|---|
| 市 | Munich |
| 期間 | 06/10/4 → 06/10/6 |
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ASJC Scopus subject areas
- Engineering(all)
これを引用
Control theoretic views on circadian rhythms. / Takeuchi, T.; Hinohara, T.; Uchida, Kenko; Shibata, Shigenobu.
Proceedings of the IEEE International Conference on Control Applications. 2007. p. 1740-1745 4067419.研究成果: Conference contribution
}
TY - GEN
T1 - Control theoretic views on circadian rhythms
AU - Takeuchi, T.
AU - Hinohara, T.
AU - Uchida, Kenko
AU - Shibata, Shigenobu
PY - 2007
Y1 - 2007
N2 - Circadian rhythms, which are observed in most of living things, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period, and have the following properties: The first property is that the oscillation is entrained by light/dark cycles; the second one is that the oscillation, especially the period of the oscillation, is robust against changes of environment. In this paper, we investigate these two properties from control theoretic viewpoints. First, considering light/dark cycle as periodic control input, we try to explain how periodic control inputs can entrain one self-sustained circadian oscillator described by a core molecular model for Drosophila by Goldbeter (1995). Second, for structural understanding of robustness of circadian rhythms, we propose an evaluation method of the robustness based on period sensitivity, and try to design some rate parameters, which are regarded as control parameters, based on some optimizations using a robustness measure, when a rate parameter is moved to outside of normal area by environmental changes.
AB - Circadian rhythms, which are observed in most of living things, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period, and have the following properties: The first property is that the oscillation is entrained by light/dark cycles; the second one is that the oscillation, especially the period of the oscillation, is robust against changes of environment. In this paper, we investigate these two properties from control theoretic viewpoints. First, considering light/dark cycle as periodic control input, we try to explain how periodic control inputs can entrain one self-sustained circadian oscillator described by a core molecular model for Drosophila by Goldbeter (1995). Second, for structural understanding of robustness of circadian rhythms, we propose an evaluation method of the robustness based on period sensitivity, and try to design some rate parameters, which are regarded as control parameters, based on some optimizations using a robustness measure, when a rate parameter is moved to outside of normal area by environmental changes.
UR - http://www.scopus.com/inward/record.url?scp=43049163957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43049163957&partnerID=8YFLogxK
U2 - 10.1109/CCA.2006.286136
DO - 10.1109/CCA.2006.286136
M3 - Conference contribution
AN - SCOPUS:43049163957
SN - 0780397959
SN - 9780780397958
SP - 1740
EP - 1745
BT - Proceedings of the IEEE International Conference on Control Applications
ER -