Control theoretic views on circadian rhythms

T. Takeuchi, T. Hinohara, K. Uchida, S. Shibata

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

Circadian rhythms, which are observed in most of living things, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period, and have the following properties: The first property is that the oscillation is entrained by light/dark cycles; the second one is that the oscillation, especially the period of the oscillation, is robust against changes of environment. In this paper, we investigate these two properties from control theoretic viewpoints. First, considering light/dark cycle as periodic control input, we try to explain how periodic control inputs can entrain one self-sustained circadian oscillator described by a core molecular model for Drosophila by Goldbeter (1995). Second, for structural understanding of robustness of circadian rhythms, we propose an evaluation method of the robustness based on period sensitivity, and try to design some rate parameters, which are regarded as control parameters, based on some optimizations using a robustness measure, when a rate parameter is moved to outside of normal area by environmental changes.

本文言語English
ホスト出版物のタイトルProceedings of the 2006 IEEE International Conference on Control Applications
ページ1740-1745
ページ数6
DOI
出版ステータスPublished - 2007
イベントJoint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC) - Munich, Germany
継続期間: 2006 10 42006 10 6

出版物シリーズ

名前Proceedings of the IEEE International Conference on Control Applications

Conference

ConferenceJoint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC)
国/地域Germany
CityMunich
Period06/10/406/10/6

ASJC Scopus subject areas

  • 工学(全般)

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