Convergent total synthesis of (+)-ophiobolin A

Kazuhiro Tsuna, Naoyoshi Noguchi, Masahisa Nakada

研究成果: Article査読

35 被引用数 (Scopus)

抄録

At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C,D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reformatsky-type reaction. The eight-membered carbocyclic B ring is efficiently constructed by a challenging ring-closing metathesis (see scheme).

本文言語English
ページ(範囲)9452-9455
ページ数4
ジャーナルAngewandte Chemie - International Edition
50
40
DOI
出版ステータスPublished - 2011 9 26

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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