Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

Yasuhiro Arimura, Kazuyoshi Shirayama, Naoki Horikoshi, Risa Fujita, Hiroyuki Taguchi, Wataru Kagawa, Tatsuo Fukagawa, Geneviève Almouzni, Hitoshi Kurumizaka

研究成果: Article

45 引用 (Scopus)

抜粋

The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. In the present study, we report the crystal structure of the heterotypic CENP-A/H3.3 particle and reveal its "hybrid structure", in which the physical characteristics of CENP-A and H3.3 are conserved independently within the same particle. The CENP-A/H3.3 nucleosome forms an unexpectedly stable structure as compared to the CENP-A nucleosome, and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A overexpressing cells.

元の言語English
ページ(範囲)7115
ページ数1
ジャーナルScientific Reports
4
DOI
出版物ステータスPublished - 2014

ASJC Scopus subject areas

  • Medicine(all)

フィンガープリント Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Arimura, Y., Shirayama, K., Horikoshi, N., Fujita, R., Taguchi, H., Kagawa, W., Fukagawa, T., Almouzni, G., & Kurumizaka, H. (2014). Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3. Scientific Reports, 4, 7115. https://doi.org/10.1038/srep07115