CTRP3 plays an important role in the development of collagen-induced arthritis in mice

Masanori A. Murayama, Shigeru Kakuta, Takumi Maruhashi, Kenji Shimizu, Akimasa Seno, Sachiko Kubo, Nozomi Sato, Shinobu Saijo, Masahira Hattori, Yoichiro Iwakura

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.

本文言語English
ページ(範囲)42-48
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
443
1
DOI
出版ステータスPublished - 2014 1 3
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

フィンガープリント 「CTRP3 plays an important role in the development of collagen-induced arthritis in mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル