CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

Masanori A. Murayama; Shigeru Kakuta; Asuka Inoue; Naoto Umeda; Tomo Yonezawa; Takumi Maruhashi; Koichiro Tateishi; Harumichi Ishigame; Rikio Yabe; Satoshi Ikeda; Akimasa Seno; Si Hua Chi; Yuriko Hashiguchi; Riho Kurata; Takuya Tada; Sachiko Kubo; Nozomi Sato; Yang Liu; Masahira Hattori; Shinobu Saijo; Misao Matsushita; Teizo Fujita; Takayuki Sumida; Yoichiro Iwakura

doi:10.1038/ncomms9483

CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

Masanori A. Murayama, Shigeru Kakuta, Asuka Inoue, Naoto Umeda, Tomo Yonezawa, Takumi Maruhashi, Koichiro Tateishi, Harumichi Ishigame, Rikio Yabe, Satoshi Ikeda, Akimasa Seno, Si Hua Chi, Yuriko Hashiguchi, Riho Kurata, Takuya Tada, Sachiko Kubo, Nozomi Sato, Yang Liu, Masahira Hattori, Shinobu SaijoMisao Matsushita, Teizo Fujita, Takayuki Sumida, Yoichiro Iwakura^*

^*この研究の対応する著者

研究成果: Article › 査読

45 被引用数 (Scopus)

抄録

The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models. C1qtnf6 -/- mice are highly susceptible to induced arthritis due to enhanced complement activation, whereas C1qtnf6-transgenic mice are refractory. The Arthus reaction and the development of experimental autoimmune encephalomyelitis are also enhanced in C1qtnf6 -/- mice and C1qtnf6 -/- embryos are semi-lethal. We find that CTRP6 specifically suppresses the alternative pathway of the complement system by competing with factor B for C3(H 2 O) binding. Furthermore, treatment of arthritis-induced mice with intra-articular injection of recombinant human CTRP6 cures the arthritis. CTRP6 is expressed in human synoviocytes, and CTRP6 levels are increased in RA patients. These results indicate that CTRP6 is an endogenous complement regulator and could be used for the treatment of complement-mediated diseases.

本文言語	English
論文番号	8483
ジャーナル	Nature Communications
巻	6
DOI	https://doi.org/10.1038/ncomms9483
出版ステータス	Published - 2015 9月 25
外部発表	はい

ASJC Scopus subject areas

生化学、遺伝学、分子生物学（全般）
化学 (全般)
物理学および天文学（全般）

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1038/ncomms9483

他のファイルとリンク

引用スタイル

Murayama, M. A., Kakuta, S., Inoue, A., Umeda, N., Yonezawa, T., Maruhashi, T., Tateishi, K., Ishigame, H., Yabe, R., Ikeda, S., Seno, A., Chi, S. H., Hashiguchi, Y., Kurata, R., Tada, T., Kubo, S., Sato, N., Liu, Y., Hattori, M., ... Iwakura, Y. (2015). CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nature Communications, 6, [8483]. https://doi.org/10.1038/ncomms9483

Murayama, MA, Kakuta, S, Inoue, A, Umeda, N, Yonezawa, T, Maruhashi, T, Tateishi, K, Ishigame, H, Yabe, R, Ikeda, S, Seno, A, Chi, SH, Hashiguchi, Y, Kurata, R, Tada, T, Kubo, S, Sato, N, Liu, Y, Hattori, M, Saijo, S, Matsushita, M, Fujita, T, Sumida, T & Iwakura, Y 2015, 'CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis', Nature Communications, vol. 6, 8483. https://doi.org/10.1038/ncomms9483

@article{745404b2ee3d4c2f9a823fa3311049c2,

title = "CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis",

abstract = "The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models. C1qtnf6 -/- mice are highly susceptible to induced arthritis due to enhanced complement activation, whereas C1qtnf6-transgenic mice are refractory. The Arthus reaction and the development of experimental autoimmune encephalomyelitis are also enhanced in C1qtnf6 -/- mice and C1qtnf6 -/- embryos are semi-lethal. We find that CTRP6 specifically suppresses the alternative pathway of the complement system by competing with factor B for C3(H 2 O) binding. Furthermore, treatment of arthritis-induced mice with intra-articular injection of recombinant human CTRP6 cures the arthritis. CTRP6 is expressed in human synoviocytes, and CTRP6 levels are increased in RA patients. These results indicate that CTRP6 is an endogenous complement regulator and could be used for the treatment of complement-mediated diseases.",

author = "Murayama, {Masanori A.} and Shigeru Kakuta and Asuka Inoue and Naoto Umeda and Tomo Yonezawa and Takumi Maruhashi and Koichiro Tateishi and Harumichi Ishigame and Rikio Yabe and Satoshi Ikeda and Akimasa Seno and Chi, {Si Hua} and Yuriko Hashiguchi and Riho Kurata and Takuya Tada and Sachiko Kubo and Nozomi Sato and Yang Liu and Masahira Hattori and Shinobu Saijo and Misao Matsushita and Teizo Fujita and Takayuki Sumida and Yoichiro Iwakura",

year = "2015",

month = sep,

day = "25",

doi = "10.1038/ncomms9483",

language = "English",

volume = "6",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

AU - Murayama, Masanori A.

AU - Kakuta, Shigeru

AU - Inoue, Asuka

AU - Umeda, Naoto

AU - Yonezawa, Tomo

AU - Maruhashi, Takumi

AU - Tateishi, Koichiro

AU - Ishigame, Harumichi

AU - Yabe, Rikio

AU - Ikeda, Satoshi

AU - Seno, Akimasa

AU - Chi, Si Hua

AU - Hashiguchi, Yuriko

AU - Kurata, Riho

AU - Tada, Takuya

AU - Kubo, Sachiko

AU - Sato, Nozomi

AU - Liu, Yang

AU - Hattori, Masahira

AU - Saijo, Shinobu

AU - Matsushita, Misao

AU - Fujita, Teizo

AU - Sumida, Takayuki

AU - Iwakura, Yoichiro

PY - 2015/9/25

Y1 - 2015/9/25

N2 - The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models. C1qtnf6 -/- mice are highly susceptible to induced arthritis due to enhanced complement activation, whereas C1qtnf6-transgenic mice are refractory. The Arthus reaction and the development of experimental autoimmune encephalomyelitis are also enhanced in C1qtnf6 -/- mice and C1qtnf6 -/- embryos are semi-lethal. We find that CTRP6 specifically suppresses the alternative pathway of the complement system by competing with factor B for C3(H 2 O) binding. Furthermore, treatment of arthritis-induced mice with intra-articular injection of recombinant human CTRP6 cures the arthritis. CTRP6 is expressed in human synoviocytes, and CTRP6 levels are increased in RA patients. These results indicate that CTRP6 is an endogenous complement regulator and could be used for the treatment of complement-mediated diseases.

AB - The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models. C1qtnf6 -/- mice are highly susceptible to induced arthritis due to enhanced complement activation, whereas C1qtnf6-transgenic mice are refractory. The Arthus reaction and the development of experimental autoimmune encephalomyelitis are also enhanced in C1qtnf6 -/- mice and C1qtnf6 -/- embryos are semi-lethal. We find that CTRP6 specifically suppresses the alternative pathway of the complement system by competing with factor B for C3(H 2 O) binding. Furthermore, treatment of arthritis-induced mice with intra-articular injection of recombinant human CTRP6 cures the arthritis. CTRP6 is expressed in human synoviocytes, and CTRP6 levels are increased in RA patients. These results indicate that CTRP6 is an endogenous complement regulator and could be used for the treatment of complement-mediated diseases.

UR - http://www.scopus.com/inward/record.url?scp=84942627280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942627280&partnerID=8YFLogxK

U2 - 10.1038/ncomms9483

DO - 10.1038/ncomms9483

M3 - Article

C2 - 26404464

AN - SCOPUS:84942627280

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 8483

ER -

CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

抄録

ASJC Scopus subject areas

UN SDG

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル