Cupolamide A: A Cytotoxic Cyclic Heptapeptide from Two Samples of the Sponge Theonella cupola

Lea S. Bonnington, Junichi Tanaka, Tatsuo Higa, Junji Kimura, Yuki Yoshimura, Yoichi Nakao, Wesley Y. Yoshida, Paul J. Scheuer

研究成果: Article査読

33 被引用数 (Scopus)

抄録

A new cyclic heptapeptide cupolamide A (1) was isolated from two samples of the sponge Theonella cupola collected in Indonesia and Okinawa. It contains two L-Val, one D-Leu, and one D-Ser, and three uncommon amino acid residues, D-homoarginine (Har), trans-4-hydroxy-L-proline (Hyp), and L-2,4-diaminobutanoic acid (Dba). The structure elucidation of 1 was performed by NMR spectroscopic techniques and the stereochemistry was determined by Marfey's method. Cupolamide A (1) was active against P388 murine leukemia cells with an IC50 = 7.5 μg/mL.

本文言語English
ページ(範囲)7765-7767
ページ数3
ジャーナルJournal of Organic Chemistry
62
22
DOI
出版ステータスPublished - 1997 1月 1
外部発表はい

ASJC Scopus subject areas

  • 有機化学

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