Curcumin attenuates oxidative stress following downhill running-induced muscle damage

Noriaki Kawanishi, Kouki Kato, Masaki Takahashi, Tsubasa Mizokami, Yoshihiko Otsuka, Atsushi Imaizumi, Daisuke Shiva, Hiromi Yano, Katsuhiko Suzuki*

*この研究の対応する著者

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Downhill running causes muscle damage, and induces oxidative stress and inflammatory reaction. Recently, it is shown that curcumin possesses anti-oxidant and anti-inflammatory potentials. Interestingly, curcumin reduces inflammatory cytokine concentrations in skeletal muscle after downhill running of mice. However, it is not known whether curcumin affects oxidative stress after downhill running-induced muscle damage. Therefore, the purpose of this study was to investigate the effects of curcumin on oxidative stress following downhill running induced-muscle damage. We also investigated whether curcumin affects macrophage infiltration via chemokines such as MCP-1 and CXCL14. Male C57BL/6 mice were divided into four groups; rest, rest plus curcumin, downhill running, or downhill running plus curcumin. Downhill running mice ran at 22. m/min, -15% grade on the treadmill for 150. min. Curcumin (3. mg) was administered in oral administration immediately after downhill running. Hydrogen peroxide concentration and NADPH-oxidase mRNA expression in the downhill running mice were significantly higher than those in the rest mice, but these variables were significantly attenuated by curcumin administration in downhill running mice. In addition, mRNA expression levels of MCP-1, CXCL14 and F4/80 reflecting presence of macrophages in the downhill running mice were significantly higher than those in the rest mice. However, MCP-1 and F4/80 mRNA expression levels were significantly attenuated by curcumin administration in downhill running mice. Curcumin may attenuate oxidative stress following downhill running-induced muscle damage.

本文言語English
ページ(範囲)573-578
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
441
3
DOI
出版ステータスPublished - 2013 11 22

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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