Current progress on structural studies of nucleosomes containing histone H3 variants

Hitoshi Kurumizaka*, Naoki Horikoshi, Hiroaki Tachiwana, Wataru Kagawa

*この研究の対応する著者

研究成果: Article査読

27 被引用数 (Scopus)

抄録

The nucleosome is the basic repeating unit of chromatin. During the nucleosome assembly process, DNA is wrapped around two H3-H4 dimers, followed by the inclusion of two H2A-H2B dimers. The H3-H4 dimers provide the fundamental architecture of the nucleosome. Many non-allelic variants have been found for H3, but not for H4, suggesting that the functions of chromatin domains may, at least in part, be dictated by the specific H3 variant that is incorporated. A prominent example is the centromeric H3 variant, CENP-A, which specifies the function of centromeres in chromosomes. In this review, we survey the current progress in the studies of nucleosomes containing H3 variants, and discuss their implications for the architecture and dynamics of chromatin domains.

本文言語English
ページ(範囲)109-115
ページ数7
ジャーナルCurrent Opinion in Structural Biology
23
1
DOI
出版ステータスPublished - 2013 2月

ASJC Scopus subject areas

  • 分子生物学
  • 構造生物学

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