CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/80- Cells and Promotes Tumor Progression

Aya Matsui, Hideaki Yokoo, Yoichi Negishi, Yoko Endo-Takahashi, Nicole A.L. Chun, Ichiro Kadouchi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Kentaro Semba, Eiji Kobayashi, Masafumi Takahashi, Takashi Murakami

研究成果: Article

46 引用 (Scopus)

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Background: Chemokines are involved in multiple aspects of pathogenesis and cellular trafficking in tumorigenesis. In this study, we report that the latest member of the C-X-C-type chemokines, CXCL17 (DMC/VCC-1), recruits immature myeloid-derived cells and enhances early tumor progression. Methodology/Principal Findings: CXCL17 was preferentially expressed in some aggressive types of gastrointestinal, breast, and lung cancer cells. CXCL17 expression did not impart NIH3T3 cells with oncogenic potential in vitro, but CXCL17-expressing NIH3T3 cells could form vasculature-rich tumors in immunodeficient mice. Our data showed that CXCL17-expressing tumor cells increased immature CD11b+Gr1+ myeloid-derived cells at tumor sites in mice and promoted CD31+ tumor angiogenesis. Extensive chemotactic assays proved that CXCL17-responding cells were CD11b+Gr1highF4/80- cells (~90%) with a neutrophil-like morphology in vitro. Although CXCL17 expression could not increase the number of CD11b+Gr1+ cells in tumor-burdened SCID mice or promote metastases of low metastatic colon cancer cells, the existence of CXCL17-responding myeloid-derived cells caused a striking enhancement of xenograft tumor formation. Conclusions/Significance: These results suggest that aberrant expression of CXCL17 in tumor cells recruits immature myeloid-derived cells and promotes tumor progression through angiogenesis.

元の言語English
記事番号e44080
ジャーナルPloS one
7
発行部数8
DOI
出版物ステータスPublished - 2012 8 29

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

これを引用

Matsui, A., Yokoo, H., Negishi, Y., Endo-Takahashi, Y., Chun, N. A. L., Kadouchi, I., Suzuki, R., Maruyama, K., Aramaki, Y., Semba, K., Kobayashi, E., Takahashi, M., & Murakami, T. (2012). CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/80- Cells and Promotes Tumor Progression. PloS one, 7(8), [e44080]. https://doi.org/10.1371/journal.pone.0044080