Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

Ryosuke Takise, Kenichiro Itami*, Junichiro Yamaguchi

*この研究の対応する著者

研究成果: Article査読

63 被引用数 (Scopus)

抄録

Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.

本文言語English
ページ(範囲)4428-4431
ページ数4
ジャーナルOrganic Letters
18
17
DOI
出版ステータスPublished - 2016 9月 2

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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